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GENERAL RISKS:
Material Safety Data Sheet - Abbott/ TAP's leuprolide = "Hazardous per OSHA criteria"
In addition to lupron itself being "hazardous", some of the added ingredients in lupron are also designated as "hazardous" ... See acetic acid glacial and benzyl alcohol. And do a google search for risks of injecting Polysorbate 80 (Tween 80).
Leuprolide may act directly via tissue GnRHR's to modulate brain function. Molecular mechanisms ... may be more complex than originally thought.
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08-24-11: Case Report - Leuprolide-induced inflammatory myopathy, severe rhabdomyolysis, and renal failure in a prostate cancer patient.
LiveStrong: Lupron Long-term Side Effects
June 2011: Revised Lupron 3.75 mg label
12-31-10: "Manic & psychotic symptoms following subcutaneous leuprolide in a male patient with no prior psychiatric history" - "PubMed in process - No Abstract available"
12-27-10: Cataracts added to list of lupron, ADT risks - read abstract of study
11-10-10: Long-term GnRHa's (lupron, leuprolide) for prostate cancer is associated with an increased risk of colorectal cancer
11-07-10: "Dangers of Leuprolide" (FDA adds warning label to prostate cancel label)
05-17-10: First case of "Serum Sickness" (hypersensitivity vasculitis) reported associated with lupron (in a prostate CA patient)
June 2009: Safety label change for Lupron 3.75 & 11.25 mg: Convulsions
2007: Leuprolide associated with ischemic stroke in young woman w/endo
Photo of bone loss after 6 months of GnRHa (scroll down page)
11-22-10: Osteoporosis Study: Lupron ("plus [another drug] used to suppress any residual oestrogen") used in study of search for key osteoporosis hormones
WHAT KIND of bone scan have you had? ... "Dual-photon absorptiometry unable to detect any appreciable bone loss with GnRHa's ...Quantitated computerized tomography always shows significant trabecular bone loss of vertebrae and hip with GnRHa's"
BEWARE of risks of bone-loss drugs prescribed to treat lupron-induced osteoporosis: ... 09-14-10: Task Force appointed to evaluate risks to bone loss drugs. And FDA may change label for bisphosphonate (bone-loss) drugs. Update 10-13-10: FDA changes label for bisphosphonate drugs
Facts about bone loss drugs, by Dr. Susan E. Brown, Ph.D
Lupron Depot = osteomyelitis
Lupron = osteonecrosis
Leuprolide acetate = osteonecrosis
Lupron/leuprolide = muscle destruction/damage
June 2009 FDA Safety Label Change for Lupron Depot 3.75 mg & Lupron Depot 11.25 mg: Convulsion
Hormone Therapy May Increase Ovarian Cancer Risk : 7-14-09
Among Cancer Outpatients, Leuprolide Med Errors Common
Millican's USA Draft Document
Lupron SUQS: Serious Unanswered QuestionS
Leuprolide & Liver Disease
Leuprolide & Granuloma Formation
"The vacuoles in the [leuprolide] granuloma are actually the [leuprolide] microcapsules"
Granuloma = foreign body reaction to leuprorelin's polymer
Leuprolide & Thromboembolic Events & Retinal Vein Occlusion
Pseudotumor Cerebri As A Side Effect
Leuprolide & Depression/Mania
Depressive symptoms associated with leuprolide
Case report: Fibromyalgia developed after leuprolide
Possible Occular effects associated with leuprolide
Another outrageous off-label use ... Lupron for acne!!
2007: Note the "deleterious effects on cognition of leuprolide"
2002 leuprolide study: Joint disorder, joint pain = 76.7% ... depression = 35.5%
1997: 2 cases of leuprolide treated leiomyomas with STRIKING VASCULAR CHANGES, and histologic features of vasculitis and atherosclerosis. These CHANGES MAY CAUSE ISCHEMIC DAMAGE if they occur in other organs
January 1992 study: Leuprolide affects intestinal motility in female rats before and after ovariectomy
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BABIES/CHILDREN:
1. IVF
2. Autism
3. Precocious Puberty
4. Gender Identity Disorder
BABIES ... 1. ** IVF -
10-15-11: Book -- "One Parent or Five" - "Are children commodities we commission ...?"
10-09-11: Sperm donors father huge 'families' in US, Canada
10-07-11: Single IVF births have increased risk of preterm birth & low birth weight
09-26-11: Geneticist: "IVF babies up to 10 times more likely to suffer rare genetic disorders"
09-22-11: Canada: "What the IVF industry is doing is creating a population of sick babies ... that is impacting all society"
08-24-11: LA Fertility Clinic sued - "embros implanted into a DIFFERENT woman"
08-13-11: Britain: "soaring numbers of mistakes at fertility clinics"
08-10-11: Two-to-one fetal reductions
08-01-11: India - IVF "blue baby" survives, needs more surgery
07-03-11: IVF in older women - "a lot of the chromosomal abnormalities are not those that are conventionally age-related. It raises the concern that some of the abnormalities might be treatment-related."
05-12-11: "Multiple-embryo IVF is too risky to allow it to continue unrestricted"
04-06-11: Twin Risks - "increased maternal hospitalizations, increased care for premature babies, and increased rates of lifelong disabilities"
02-10-11: UK - In an article promoting a new technique, it is admitted that "many of the embryos produced in a typical IVF cycle have the wrong # of chromosomes or significant chunks of DNA missing or duplicated ... (&) looking at embryos under a microscope ... cannot distinguish embryos with lethal chromosome problems from those that are healthy."
02-09-11: Denmark/Sweden - In a study of offspring of paternal cancer patients, those conceived by "ART had a 20% increased risk for major congenital abnormalities compared with children conceived naturally".
01-07-11: UK - Alobar holoprosencephaly (major part of brain not yet formed) in one IVF twin - dies at 8 months. (story makes no mention of potential causality to IVF)
12-21-10: BMJ editorial re: Single Embryo transfer - "Doctors managing infertile couples are no longer entitled to take risks with the health of the next generation."
12-3-10: Belgian court approves "wrongful life"
10-18-10: High rate of genetic abnormalities in IVF embryos - 2 out of every 3 IVF embryos fail to develop
08-11-10: Opinion Piece Considers Ethics of Passing on Defective Genes Through IVF, ICSI
07-22-10: 100's of British IVF embryos donated 'without consent'
07-20-10: IVF Babies May Be More Prone To Childhood Cancers
06-14-10: France - ART Doubles Risk of Deformity
06-14-10: Croatia: One of oldest IVF mom of twins loses 1-month old newborn
06-13-10: "Doctors should warn of IVF defect risks"
06-13-10: ART birth defects = "a public health issue"
06-09-10: Canada: "serious medical problems and steep costs associated with twins & triplets"
06-08-10: Sex selection = Booming Business
05-25-10: Ovulation inducing drugs (oral and injection) = twice the risk of autism
05-20-10: Fertility treatments linked to autism risk
05-04-10: (UK) Story relating IVF twins' health problems (no connection identified with IVF/drugs)
04-30-10: Couple writes book about embryo mix-up
04-27-10: Congenital malformations and ART
04-27-10: UK story - IVF Twins needed 23 blood transfusions in 1st year
04-1-10: Orthodox blog - "4 reasons you might be aborted. An open letter to fetal humans"
04-13-10: UK - No connection discussed re: IVF toddler & death from leukemia
03-30-10: On the matter of Gendercide
03-28-10: Study - Blastocyst-stage embryo transfers = higher risk of preterm birth and congenital malformations among singletons
03-18-10: Study - IVF/ICSI = 53% greater risk of preterm, & doubling in odds of very premature birth
03-16-10: Study: Triplet births rising & death rates high
03-13-10: "Alert: In Vitro Culture Medium Shown to Influence Birthweight of Singleton Newborns"
03-12-10: IVF Babies Risk for ADHD = 11 Times Higher
01-19-10: Increased risk of congenital heart disease in ART kids
02-01-10: Skewed X inactivation & IVF-conceived infants
02-28-10: Patient's Doctor blogspot: Misusing technology in an IVF clinic - high tech mumbo jumbo and hocus pocus
02-23-10: IVF children might be at risk of infertility themselves, scientists say
02-17-10: IVF babies 'at risk for complications'
02-17-10: Study: 27.1% of IVF babies had ADHD
02-26-10: "Do fertility treatments raise autism risk?"
02-25-10: Non-identical IVF twins have increased risk of neonatal complications
02-23-10, Scientific American: Test Tube Trouble - "IVF may alter gene expression implicated in chronic metabolic disorders"
02-23-10, UK - "Infertility Time Bomb: IVF children have higher risk of infertility, obesity, diabetes"
02-22-10: "IVF babies may raise risk of diabetes, hypertension, cancer"
02-21-10: Celine Dion "bruised and numb" from IVF
02-17-10: IVF babies more likely to have AHDH, depression, binge drinking
10-14-09: Risks of PGD (preimplantation genetic diagnosis) not being adequately disclosed
03-23-09: UK warns IVF = 30% Higher Risk of Genetic Abnormalities
2009: Study: Congenital malformations in Swedish infants after IVF
11-18-08: IVF Singletons - Increased Risk for Birth Defects (cleft lip, GI & septal heart defects)
07-27-07: More health risks found in IVF babies - Scientist Suggests IVF Children Should Be Monitored Into Adulthood
IVF Babies more prone to stillbirth
IVF, ICSI = Fourfold increase in risk of stillbirths
"Significant increased risk of birth defects associated with assisted human reproduction"
"Picture emerging of genetic risks of IVF"
Findings Suggest Some Birth Defects Occur More Often Among ART-conceived infants
"ART Strongly Associated With Numerous Adverse Outcomes in Massachusetts."
3 IVF Siblings of CA. Octuplets Have Disabilities
2008 Case Report: 2 month old IVF baby with congenital mesoblastic nephroma
Use of Lupron/leuprolide During Pregnancy Has Resulted In Fetal and Newborn Death
"ICSI" overused, can transmit genetic defects
IVF Clinic online ads for PGD = minimization of risks
02-10-09: 3 of Octomom's other IVF kids have disabilities
02-08-02: Brain worry over IVF kids - higher than normal chance of cerebral palsy
2006: Constriction band syndrome occurring in setting of IVF & advanced maternal age
2006: Institute of Medicine Report on prematurity: $51,600 cost per premature infant
Mention is made in this article of the fact that Premature infants < 1200 grams (2 pounds, 10 ounces) = Disabled = Medicaid eligible for SSI
2007: Clinic to weed out embryos with a squint
1997: ICSI = Twice as likely to have major birth defect, 50% more likely to have minor defect
CHILDREN: #2 ... ** Autism -
05-19-11: Maryland physician board charges Geiers
05-04-11: Autism doctor's license suspended
RationalWiki: "Lupron Therapy - discredited treatment ... irresponsible and dangerous"
08-03-10: "Lupron carries a risk of bone damage, stunted growth and heart trouble and can render children impotent ... we cannot be using these children as guinea pigs ... we have very significant concerns about irreversible damage to sexual function and the brain and sex organs of these children."
05-25-10: Ovulation inducting drugs (oral and injection) = twice the risk of autism
05-21-10: Autistic children 3 to 4 times more likely to be IVF kids
05-20-10: Fertility treatments linked to autism risk
04-26-10: Series on Dubious Autism Treatment [Lupron] Wins Journalism Award
Autism & Lupron = Playing with Fire by Kathleen Seidel
'Evolution of the Lupron Protocol' by Kathleen Seidel (Index to many articles)
ScienceBlog: Why not just castrate them (Part 2): The mainstream media finally notices the Geiers' Lupron Protocol.
"Toxic Treatments for Autistic Children"
Abbott says 'no scientific evidence to justify further lupron/autism research'
The high financial cost of Lupron 'therapy'
"Miracle drug" lupron for autism' = "junk science, horror, irresponsible"
05-21-09: Chicago Tribune - 'Serious Flaws in Lupron/Autism Research'
Psychology Today Blog / Jean Mercer PhD: Why would a reputable physician use this powerful drug for a non-approved purpose?
The Autism/Lupron Protocol: "a misunderstanding of the science"
05-25-09: Lupron 'science' = "Science so bad it doesn't even qualify as junk science"
Do the Geiers hate autistic children?
"Stretch[ing] the truth" - Geier's Lupron/Autism "treatment"
A Dubious Diagnois (autism/lupron)
Further Comment on the Geiers' Lupron Work
Pathophilia: TAP's Patent Application to give Lupron to Autistic Children
Lupron "franchises" for autism?
BlipTV: Loopy Lupron - a Horrible Mistake or Something Worse?
Crock O' Crap Alert ... 04-21-08: Lawyer states "The drug lupron has been used for many years to lower testosterone and has an excellent safety record according to the Geiers'"
KIDS: #3 ... ** Precocious Puberty -
08-16-11: Lupron 3-month formulation (2 strengths) approved for PP ("convulsions have been observed")
Millican's '05 Public Comment to FDA re: risks of leuprolide's use as 'tool' on healthy children
Susan Hayward's '05 Public Comment to FDA against testing of GnRHa's in puberty disorders
Melissa Harry's '05 Public Comment to FDA against testing of GnRHa's in puberty disorders
Additional 2005 Public Comments posted on FDA website re: leuprolide's use in children
FDA's 11-15-05 Pediatric Advisory Committee, Pediatric Ethics Subcommittee's Mtg - Summary of Submitted Panel Comments (see p. 141)
45% of girls in Precocious Puberty study using leuprolide had "decreased bone accretion"
KIDS #4: .... **** Gender Identity Disorder
10-17-11: Controversial therapy for pre-teen transgender raises questions
07-11-07: Lupron Depot to "pause the child within". Psychiatrist calls Lupron treatment "a modern form of child abuse".
Lupron is touted as "saving kids the anguish of ... everything from depression ... to suicide" - YET lupron has been reported to have caused everything from depression to suicide! (See 'General Risks' above, & 'AERS' page)
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FEMALE:
1. IVF
2. Egg Donor
3. Endometriosis
4. Fibroids
5. Surrogacy
6. Egg Freezing
7. Stem Cells / Cloning
FEMALE: #1 ... ** IVF -
10-27-11: Dutch Study: Fertility treatment raises tumor risk - Women given fertility 'drugs' "have an increased risk of developing borderline ovarian tumors."
10-17-11: Celebrity undergoes several unsuccessful IVFs, and announces has breast cancer (no causality to IVF drugs mentioned or considered)
09-28-11: Study - Donor Eggs may raise pregnancy complication risks
08-14-11: IVF mistakes treble in Britain - calls for more transparency in fertility industry
07-03-11: IVF in older women - "a lot of the chromosomal abnormalities are not those that are conventionally age-related. It raises the concern that some of the abnormalities might be treatment-related."
06-02-11: Octomom doc loses license
05-16-11: Brazilian fertility expert suspected of creating large numbers of IVF children not genetically related to (deceived) parents
03-24-11: Brain-wasting prions found in urine-based fertility hormone
02-10-11: India movs towards regulation of assisted reproduction
02-07-11: Women at Risk of Pre-Eclampsia After Using Donated Eggs
01-31-11: BMJ editorial - IVF may be associated with higher rate of maternal deaths than previously reported
01-28-11: Maternal IVF deaths rare but relevant ... #'s may be underestimated
11-24-10: Singapore IVF mix-up = "human error"
11-23-10: IVF with donor eggs = increased gestational hypertension, preeclampsia, & premature delivery
11-18-10: Fertility doc, about the implaintation of 12 embryos in Octomom: "I can't fault [octomom's fertility doc's] judgement, to be honest"
10-31-10: "Depot Leuprolide Acetate Does Not Benefit IVF Patients with Endometriosis"
10-24-10: British blog - "I regret my IVF"
10-23-10: UK: "IVF Destroyed My Family"
10-18-10: Two out of every Three IVF embryos fail to develop
09-14-10: Fertility Experts Caution Against IVF Tourism
07-27-10: Story about (IVF) pregnant woman who developed breast cancer (no causal connection between cancer & IVF is identified or mentioned)
07-27-10: IVF moms face 3 times higher death risk
06-28-10: Heavy women's miscarriage risks higher after IVF
06-15-10: "World's oldest IVF mom lies dying"
06-15-10: doc of dying oldest IVF mom was "co-conspirator in medical experiment"
05-29-10: Folly of Designing Babies to Order
05-18-10: Australian scientists predict reliance on IVF conception rather than sex
2008 Case Report: Maternal death after oocyte donation/IVF in older woman
05-02-10: Australia fears costs & complications (like in U.S.) from implanting multiple embryos
04-27-10: Wales IVF clinic sued for losing 2 embryos . Other 'blunders' also noted
04-26-10: Severe case of OHSS with Pulmonary Thromboembolism (Contains review of OHSS)
04-25-10: UK - Bluders at IVF Clinics have 'almost doubled in past 12 months'
04-24-10: UK - Watchdog Under Fire as Number of IVF Blunders Soar
04-21-10: FDA Imposes Sanctions: Genetics & IVF Institute IRB ordered to stop enrollment in ongoing device studies
04-21-10: UK - Cheap fertility drugs = risks of multiple births
04-10-10: Less than 2.2% of women over 43 years old find success with IVF
03-31-10: Note in this UK story about post-IVF aggressive breast cancer that there is NO mention of causal connection
03-14-10: "... No long-term studies on women who've taken Lupron" ... "Where are the investigative journalists?"
03-13-10: UK clampdown on # of embryos implanted due to "growing fears about their health & cost to NHS"
03-04-10: Be aware of costs and risks of IVF
03-03-10: Dr says ART/ IVF "implies a high cost of human lives"
02-24-10: Increased risk of preterm, low-birth weight after IVF/ICSI
02-23-10: "IVF & stillbirth - a prospective follow-up study"
1-17-10: Fertility Forum - 'leg, then entire side of body NUMB after lupron'
Blog: 29 year old has stroke days after starting Lupron for IVF (see 09-05-09 entry. See also "Lupron caused my wife's stroke" (09-08-09 entry)
UK: Damages awarded for stroke during IVF (2005):
02-26-10: UK - "IVF made me suicidal too"
09-25-09: Embryo mix-ups stun parents in Ohio, Louisiana
07-09: Internal Jugular Venous Thrombosis after IVF
02-28-09: Picture Emerging on Genetic Risks of IVF
12-12-06: UK - tracking women who take lupron is "surely essential"
Massive ascites & hydrothorax after leuprolide during ART
OHSS, minimal ascites with leuprolide use in ART (1994)
'IVF and Cancer', by Dr. Jennifer Schneider
World's Oldest IVF Mom Dies of Breast Cancer - Toddler Twins Orphaned. Tumor Developed Shortly After IVF Births
Cancer Risks after Exposure to Treatments for Ovulation Induction - Journal of Epidemiology 02-01-09
Professor Links Adverse Health Outcomes to ART in Massachusetts
Risks: Infertility and Assisted Reproduction by Dr. Suzanne Parisian
Population-based Study of Maternal & Perinatal Outcomes Associated with ART in Massachusetts
IVF: Becoming Common & Costly to Healthcare($1 billion in 2005 dollars)
Selective Reductions - The Truth About Multiple Births
Myocardial Infarction (Heart Attack) During IVF with leuprolide
Myocardial Infarction during ovarian stimulation with leuprolide
Pituitary apoplexy after leuprolide injection for ovum donation
Conclusion that microflare leuprolide is superior to antagonist in poor responders "invalidated"
Leuprolide's Effects on Pregnancy
Gena Corea's Testimony for Millican's '97 Medical Malpractice Tribunal
Harm & Death from Hyperstimulation of Ovaries
04-07: Higher incidence of maternal & perinatal morbidity associated with IVF pregnancies
UK IVF embryo mix-up disaster
Millican's 03-27-03 written Congressional Testimony on risks of lupron & ART
Millican's 03-27-03 oral Congressional Testimony on risks of lupron & ART
Millican's 04-02 Testimony for Senate HELP Committee Briefing on risks of lupron & superovulation/cloning
Millican's 09-01 comment to Senate HELP Committee on risks of lupron & embryonic stem cell research
Millican's '96 Read for OBOS's 'Reproductive Technologies Chapter' update
08-04-96 Boston Globe: RESOLVE receives hundreds of thousands of dollars from fertility drug manufacturers (including money from TAP)
History of superovulating women, stealing eggs and embryos from trusting women, and selling them to unsuspecting women
02-22-10: Multiple IVF pregancies = big risk to mom and child
Expanding the use of IVF (a "happy form of medicine") to the Fertile for gender and trait selection, and disease detection
09-08: Cancer Risk After Exposure to Treatments for Ovulation Induction
2007: "Clomiphene and possibly progesterone may increase thyroid cancer risks"
10-02: IVF-Induced Alterations in Coagulation & Fibrinoloysis
10-02: Risks associated with ICSI, embryo freezing, & PGE
1998 paper by deMelo-Martin: IVF & Risks to Women's Health
FEMALE: #2 ... ** Egg Donor -
www.Eggsploitation.com
10-26-11: UK - Fears of "intensive [egg] farming" at fertility clinics
10-23-11: UK "Human Egg Farms" - women superovulated to produce up to 85 eggs at one time.
03-30-11: Egg Donor Interview - Linda* in Los Angeles
03-15-11: Interview with Jennifer Lahl re: risks of egg donation
02-10-11: India moves towards regulation of assisted reproduction
01-25-11: True Cost of Egg Donation - A Pretence of Altruism Cloaks the Mercenary & Exploitative Reality
01-09-11: Women at risk donating eggs
11-25-10: IVF pregnancies with donor eggs might be more at risk for developing preeclampsia
11-14-10: Donated eggs for embryonic research: The risk to women is too great
08-30-10: Women stimulated for 'just in case' scenario! ... Clinic says: "Sometimes we will lose the eggs if we can't find a customer, but it's a trade-off ... This way, we can guarantee a steady supply." (Note: a "trade-off" for WHOM?)
07-27-10: Donor eggs linked to high blood pressure & placenta complications
07-08-10: The Eggsploited: When 2 Markets Collide (film review)
05-10-10: Payments to Egg Donors Prompts Scrutiny
04-28-10: Experience of an Anonymous Egg Donor ... Stage 4 Cervical Cancer & Infertility
04-27-10: re: Egg Brokers - Read the Fine Print
04-22-10: The Resistance: Sex, Lies, & Greed by Jennifer Lahl
03-24-10: Ads Soliciting Egg Donors Violate Guidelines
03-17-10: Donor Bill would help prevent exploitation
03-14-10: " ... No long-term studies on women who've taken Lupron." ... "Where are the investigative journalists?"
03-12-10: ? Kansas to be 1st state to mandate record keeping of IVF/egg harvesting
03-03-10: Bioethics Expert Suggests Women Reconsider Plan to Donate Eggs to Clinics
03-02-10: Lawmakers want more warnings for egg donors
02-25-10: Bringing meaning to egg donor's death - seeking research on egg donations by Dr. Jennifer Schneider
HandsOffOurOvaries.com
Diary of a Nameless, Faceless Egg Donor: "I was pretty sure I was going to die"
Pituitary apoplexy after leuprolide injection for ovum donation
Woman X: my story as an egg donor
"It's Time for an Egg-Donor Registry and Long-Term Follow-Up" - 11/07 Testimony by Dr. Jennifer Schneider
Harvard's ESCR Team Will Not Use Lupron For Its Egg Donors
Egg donor now suffers with cancer (in 'Comment' below article)
Shortage of eggs for research, yet growing # of research applications to use eggs
Calla Papademas' Story on Vimeo
7-14-08 Google TechTalk: Ethics of egg donation by Jennifer Lahl
OBOS '05: Time to weigh the risks
OBOS '02: Concerns about Lupron
02-19-10: Egg donors should be told of possible stem cell use
2007: Estimating risk of OHSS
FEMALE: #3 ... ** Endo -
National Women's Health Network 11/12-08 Cover Story - Lupron: What Does It Do To Women's Health?
02-15-11: Oral contraceptives cost $7000 less than leuprolide, and are equally as effective as leuprolide
02-07-11: Fertility & Sterility: Continuous Oral Contraceptives appear equally effective as leuprolide in treatment of endo-associated pelvic pain
10-31-10: "Depot Leuprolide Acetate Does Not Benefit IVF Patients with Endometriosis"
Clinical trials review '00: Evidence for efficacy of leuprolide acetate is weaker than other treatments
Endo MD: "Lupron Doesn't Work"
ERC (Endometriosis Research Center) 2003 Survey: "48.19% indicated Lupron was INTOLERABLE and NOT HELPFUL AT SYMPTOM RELIEF"
ERC 2003 survey: "Use of [Lupron] Prior To An Endometriosis Diagnosis" is "inherently flawed"
ERC 2003 survey: "23.33% Suffered Lasting Effects For UP TO 5 OR MORE YEARS after Lupron"
Leuprolide & Stroke in young women
Conclusion: "Bone loss not fully recovered up to 6 years after 'treatment' - HRT had no effect"
Endometriosis Association has history of receiving hundreds of thousands of dollars from GnRHa manufacturers (i.e. TAP)
HRT nearly doubles risk of lung CA
FEMALE: #4 ... ** Fibroids -
Massive ascites after leuprolide for fibroids (1992)
1997: 2 cases leuprolide treated leiomyomas with STRIKING VASCULAR CHANGES and histologic features of vasculitis and atherosclerosis. These CHANGES MAY CAUSE ISCHEMIC DAMAGE if they occur in other organs.
FEMALE: #5 ... ** Surrogacy -
10-25-11: 'Baby trafficking' scandal just the tip of IVF/surrogacy iceberg
08-13-11: Scam targeted surrogates as well as couples
08-11-11: Lawyer selling babies for up to $150,000 each ... Millions in costs born by taxpayers
08-10-11: "Baby-Selling Ring ... The scheme was designed to create an inventory of unborn children [to sell]."
04-11-11: Hague Conference to work on Surrogacy issues
04-05-11: India - "In case of death of surrogate mother, Max New York Life will pay R2lakh to the family of the surrogate ... so far there haven't been any claims"
02-15-11: UK - Failed surrogacy agreement
02-10-11: India moves towards regulation of assited reproduction & surrogacy
06-05-10: "India's Rent-a-Womb Industry Faces New Restrictions"
02-25-10: UK - "I gave birth to my friend's baby & it nearly cost me my life"
FEMALE: #6 ... ** Egg Freezing -
06-26-10: " ... There are not enough scientific studies to prove that children conceived from egg freezing will not have problems. ..."
FEMALE: #7 ... ** Cloning, Stem Cells -
06-20-01: Congressional Hearings on Stem Cells & Cloning
11-17-10: Risks of Human Embryonic Stem Cell Clinical Trials for Spinal Chord Injury
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MALE:
(ADT = Androgen Deprivation Therapy = Lupron/leuprolide)
10-07-11: PSA Testing "does more harm than good"
09-26-11: Lupron "reduced senator's cognitive abilities & made him 'fuzzy'"
08-23-11: Oncologist (prescribing new prostate cancer vaccine) states: "The problem with drugs like Lupron is that the cancer eventually learns how to adapt and defeat the hormonal therapy."
01-07: Leuprolide + Radiation = Shortened Penile Length
Chronic Lupron & Osteoporosis
11-22-10: "Case Study of Lupron on Gentlemen" - "The intestinal problems are almost obligatory when it comes to lupron for prostate cancer .... take some anti-importance drugs" ... (an off-beat ' piece' due to the semantics and mistranslations - Scroll down)
05-17-10: First case of "Serum Sickness" (hypersensitivity vasculitis) associated with lupron use reported
05-03-10: FDA Conducting Safety Review of lupron/GnRHa's
07-09-08: Survival Following Primary Androgen Deprivation Therapy Among Men with Localized Prostate Cancer
Periodontal disease in 80.5% of men on ADT (3.7% of men not on ADT)
Lupron on list of drugs that may cause impotence
2/1/10 Experts issue warning: "All hormone therapies [ie Lupron, leuprolide, etc] for prostate CA can have increased risk of cardiovascular disease, diabetes, death" Expert's advisory appears in 2-16-10 issue of Circulation
09-24-09: Lupron = "very large increased risk of developing various major heart problems"
Early studies showed lupron caused fibrosis & damage in testes
2008: New finding "may be final nail in [Lupron's] coffin"
Cancer 2009: Review of major adverse events of ADT
Warnings re: cardiovascular and metabolic effects
09-04-09: Leuprolide linked with 96% higher risk of death among those with heart problems
09-22-09: Lupron = 34% increased risk of heart failure, 30% increased risk of ischemic disease
"Fractures ~ 50% more likely in men treated with ADT"
If Amy Doseretz' study had been submitted to FDA, "Lupron would never have been granted approval for prostate CA" (20% increase in mortality - see "FDA Approval would be denied")
08-25-09: Leuprolide - "Dangerous", Heightened Risk of Death" in some men
09-04-09: Dr: 'More Cautions with leuprolide treatment'
Metabolic complications with ADT
08-23-08: 20% greater risk of dying with leuprolide + radiation versus radiation alone
Cancer 2008: Review of cognitive effects of ADT
Lupron "rarely helps" Prostate Cancer
Lupron for Prostate CA = "more harm than good"
Androgen deprivation (leuprolide) is associated with increased rate of bone loss
NEJM: ADT increases risk of fracture
Prostate CA, leuprolide & cognitive effects
Men on lupron = osteoporosis
Male breast CA during treatment with leuprolide for prostate CA
PSA Test: "fairly small benefit, pretty big risks"
PSA Test: "More harm than good"
03-03-10: PSA screening not recommended for most men
2002: Quality of life 'stinks' with ADT
Humorous spin on Lupron-induced MEN-opause
blog: Tumor GREW on Lupron (scroll down)
CancerCompass Message Board: "Lupron puts a thick sticky membrane on the outside of the prostate making nerve sparing impossible" (see 11-26-05 entry)
10 reported cases of pituitary apoplexy after leuprolide injection in prostate cancer 'treatment'
03-05-10: Empower patients: "Let's say a physician treats an 80 year old man with Lupron rather than surgery and radiation. Testosterone levels will decline and the patient is more likely to surffer a heart attack or fall and break his hip ... which he'll probably die from."
03-14-10: Lupron can cause gynocomastia
2005: Insulin resistance as an adverse effects of leuprolide and bicalutamide treatment
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